SPYRE THERAPEUTICS INC - Security Detail

Period	Total Value	Value Change	Total Holders	Holder Change
2024-06-30	$1.18B	-	109	-
2024-09-30	$1.51B	+27.8%	120	+10.1%
2024-12-31	$1.39B	-7.9%	126	+5.0%

Institution	Value	Shares	% of Portfolio
FAIRMOUNT FUNDS MANAGEMENT LLC	$93.5M	4,018K	9.3%
VR ADVISER, LLC	$62.5M	2,685K	4.3%
COMMODORE CAPITAL LP	$46.3M	1,988K	3.4%
AFFINITY ASSET ADVISORS, LLC	$19.2M	824K	2.6%
BRAIDWELL LP	$60.0M	2,578K	1.8%
PERCEPTIVE ADVISORS LLC	$59.9M	2,574K	1.7%
LOGOS GLOBAL MANAGEMENT LP	$11.6M	500K	1.4%
RTW INVESTMENTS, LP	$84.3M	3,621K	1.3%
PARADIGM BIOCAPITAL ADVISORS LP	$35.6M	1,527K	1.2%
BOXER CAPITAL MANAGEMENT, LLC	$10.9M	466K	0.9%
IKARIAN CAPITAL, LLC	$6.6M	282K	0.9%
HIGHVISTA STRATEGIES LLC	$2.2M	95K	0.8%
B GROUP, INC.	$1.2M	50K	0.7%
EMERALD MUTUAL FUND ADVISERS TRUST	$9.0M	386K	0.6%
DRIEHAUS CAPITAL MANAGEMENT LLC	$65.3M	2,803K	0.5%
PROSIGHT MANAGEMENT, LP	$1.9M	80K	0.5%
EMERALD ADVISERS, LLC	$12.7M	546K	0.5%
SIREN, L.L.C.	$8.7M	374K	0.4%
EFG ASSET MANAGEMENT CORP.	$1.9M	82K	0.3%
DEERFIELD MANAGEMENT COMPANY, L.P.	$10.5M	450K	0.2%
DEEP TRACK CAPITAL, LP	$5.1M	219K	0.2%
JEFFERIES FINANCIAL GROUP INC.	$28.3M	1,216K	0.2%
POLAR CAPITAL HOLDINGS PLC	$17.5M	750K	0.1%
SOROS FUND MANAGEMENT LLC	$5.8M	250K	0.1%
NBW CAPITAL LLC	$0.5M	19K	0.1%

Ticker	Exchange	Security	Similarity Score	Common Holders	Total Holders
ORKA	US	ORUKA THERAPEUTICS INC	0.106	7	66
IKT	US	INHIBIKASE THERAPEUTICS INC	0.097	3	31
DRUG	US	BRIGHT MINDS BIOSCIENCES INC	0.067	2	30
PCSC	US	PERCEPTIVE CAPITAL SOLUTIONS	0.063	2	32
APGE	US	APOGEE THERAPEUTICS INC	0.059	9	153
IMTX	US	IMMATICS NV	0.048	4	84
ABVX	US	ABIVAX SA-ADR	0.043	2	46
ATXS	US	ASTRIA THERAPEUTICS INC	0.038	4	105
PHVS	US	PHARVARIS NV	0.036	2	55
MRUS	US	MERUS NV	0.033	6	182
DNTH	US	DIANTHUS THERAPEUTICS INC	0.033	3	92
VRDN	US	VIRIDIAN THERAPEUTICS INC	0.029	5	170
NUVL	US	NUVALENT INC-A	0.029	6	205
ERAS	US	ERASCA INC	0.028	4	141
CNTA	US	CENTESSA PHARMACEUTICALS-ADR	0.028	3	106
ELVN	US	ENLIVEN THERAPEUTICS INC	0.028	3	107
SLNO	US	SOLENO THERAPEUTICS INC	0.025	4	158
BCAX	US	BICARA THERAPEUTICS INC	0.025	2	80
VERA	US	VERA THERAPEUTICS INC	0.024	4	168
COGT	US	COGENT BIOSCIENCES INC	0.024	4	168
CRGX	US	CARGO THERAPEUTICS INC	0.021	2	95
EWTX	US	EDGEWISE THERAPEUTICS INC	0.021	4	195
YMAB	US	Y-MABS THERAPEUTICS INC	0.019	2	107
ESTA	US	ESTABLISHMENT LABS HOLDINGS	0.018	2	112
VRNA	US	VERONA PHARMA PLC - ADR	0.017	3	175